Today's interleague showdown between the Philadelphia Phillies and Cleveland Guardians has strong implications for both teams. Let’s take a look at my Phillies vs Guardians prediction for May 10 at Progressive Field.

Preview of Phillies vs Guardians Prediction

First pitch is set for 6:10 PM ET at Progressive Field, and this is a game that’s caught the attention of bettors due to Cleveland’s strong underdog performance. The Phillies vs Guardians picks point toward a tight matchup, especially with the Guardians coming in at home after covering 3 of their last 5 spreads. The Phillies, meanwhile, are looking to rebound after a slightly rough ATS stretch.

Injury Report for Phillies vs Guardians

Injuries could play a major role in how this Phillies vs Guardians prediction plays out. The Guardians are dealing with a stacked injury report, including key pitchers like Shane Bieber and Sam Hentges. The Phillies are in better shape, though Ryan Burr and José Ruiz are still sidelined.

Phillies:

Guardians:

Who is Favored to win Phillies vs Guardians?

Despite the Guardians’ injuries, my Phillies vs Guardians pick leans in their favor on the run line. The Rithmm model gives Cleveland a 64.9% probability to cover +1.5 at -157 odds, indicating strong value as a home underdog with the run buffer.

Phillies vs Guardians History

Let’s break down the recent Phillies vs Guardians trends:

• Phillies ATS Record (Last 5): 2-3-0
• Guardians ATS Record (Last 5): 3-2-0
• Phillies Away ATS: 2-2-0
• Guardians Home ATS: 1-0-0
• Phillies as Favorite ATS: 2-3-0
• Guardians as Dog ATS: 2-0-0

How many times has Guardians beat Phillies?

This specific season hasn’t featured a head-to-head matchup yet, but the Phillies vs Guardians trends favor Cleveland when getting the run line at home.

Model Used For My Phillies vs Guardians Best Bet Prediction

I’m using Rithmm’s Pre-Built MLB Model, which incorporates scoring averages, historical performance, and injury impact. Based on the model:

• Phillies expected score: 3.5
• Guardians expected score: 4.5

This supports my Phillies vs Guardians prediction that leans Cleveland’s way.

What chance does Guardians have of beating Phillies?

The Guardians have a 64.9% chance to cover the +1.5 run line based on Rithmm’s predictive data. That’s a strong edge for bettors looking at Phillies vs Guardians picks today.

Best Odds for Phillies vs Guardians

FanDuel currently offers the best odds for the Guardians +1.5 at -154, making it the top pick in our Phillies vs Guardians Best Odds analysis.

My Pick for Phillies vs Guardians

My Phillies vs Guardians pick is Guardians +1.5 (-154 at FanDuel). The model’s 64.9% probability plus recent trends make this a top-rated bet, even with Cleveland’s injury concerns.

Explore More Phillies vs Guardians Predictions

Looking for more AI-powered predictions? Check out:

• AI Sports Betting insights for smarter decision-making.
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• AI MLB Player Props for deeper in-game data

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