The Miami Marlins head to Wrigley Field to take on the Chicago Cubs in a May 14 NL matchup. Let’s take a look at my Marlins vs Cubs prediction and what the data says about the best bet for tonight’s game.

Preview of Marlins vs Cubs Prediction

First pitch is scheduled for 7:40 PM ET at Wrigley Field. The Cubs enter this contest as moderate home favorites despite injury issues, while the Marlins look to snap out of a tough stretch on the road. Both teams have identical recent ATS records (2-3), but Chicago’s offense and pitching depth give them an edge in this Marlins vs Cubs prediction.

Injury Report for Marlins vs Cubs

Injury depth plays a major role in shaping today’s Marlins vs Cubs picks.

Cubs Injury Report:

• Javier Assad, Justin Steele, Elijah Morgan (D60 - Oblique/Elbow)
• Ryan Brasier, Shota Imanaga (D15 - Hip/Leg)
• Tyson Miller (D60 - Hip)
• Ian Happ (D10 - Oblique)

Marlins Injury Report:

• Griffin Conine, Eury Pérez, Andrew Nardi, Bryan Hoeing (D60 - Arm/Elbow/Back/Shoulder)
• Ryan Weathers, Declan Cronin (D15 - Forearm/Hip)
• Otto Lopez, Dane Myers, Robert Brantly (D10 - Ankle/Oblique/Lat)

Both lineups are missing key players, but Miami’s rotation looks particularly depleted—critical context for this Marlins vs Cubs Best Bets analysis.

Who is Favored to Win Marlins vs Cubs?

According to the latest Marlins vs Cubs prediction data, the Cubs are favored by 1.5 runs. Model projections and market odds both tilt toward Chicago as the more complete team right now.

Marlins vs Cubs History

Let’s take a look at recent Marlins vs Cubs trends:

• Cubs ATS Record (Last 5): 2-3-0
• Marlins ATS Record (Last 5): 2-3-0
• Cubs at Home: 1-1-0
• Marlins on the Road: 2-3-0
• Cubs as Favorite: 1-1-0
• Marlins as Underdog: 1-1-0

This Marlins vs Cubs prediction leans on the home-field advantage and deeper model rating for Chicago, despite the equal recent records ATS.

How Many Times Has Cubs Beat Marlins?

While this article focuses on today’s context, recent trends show the Cubs have historically held the edge at Wrigley Field. That’s another factor supporting today’s Cubs vs Marlins picks.

Model Used for My Marlins vs Cubs Best Bet Prediction

The Rithmm Pre-Built MLB model powers this Marlins vs Cubs prediction.

It analyzes injuries, recent performance, pitching matchups, and advanced metrics like xERA, run expectancy, and bullpen volatility to create high-confidence predictions.

What Chance Does Cubs Have of Beating Marlins?

The Rithmm model projects a final score of Cubs 5.5, Marlins 3.5, giving Chicago a 55.1% win probability to cover the -1.5 run line.

‍

This win edge combined with value pricing creates a strong Marlins vs Cubs pick on the run line.

Best Odds for Marlins vs Cubs

Let’s compare the best Marlins vs Cubs odds available:

• Best Line: SugarHouseNJ (-1.5, +110)
• Other top options: FanDuel (+102), WilliamHill (+100)

With the Cubs favored, sharp line shopping is crucial to getting maximum value from this Marlins vs Cubs pick.

My Pick for Marlins vs Cubs

The best bet in this Marlins vs Cubs prediction is:

Cubs -1.5 (+110)

The model gives them a 55.1% edge on the run line, and with the Marlins' pitching depth heavily impacted, there’s strong value backing Chicago to win by multiple runs.

Explore More Marlins vs Cubs Predictions

Looking for more AI-powered predictions? Check out:

• AI Sports Betting insights for smarter decision-making.
• MLB AI Sports Predictions for advanced game insights.
• Computer MLB Picks for expert computer-driven predictions.
• MLB PrizePicks for AI PrizePick predictions.
• AI MLB Player Props for deeper in-game data

This AI sports betting analysis is just a glimpse of what you can expect when using Rithmm. Whether you’re looking to refine your betting strategy or want to explore in-depth data trends, Rithmm's AI tools for sports betting has all you need. Don't miss out on making more informed decisions—download the Rithmm app today for full access to our AI baseball predictions, MLB Computer Picks, AI Player Props, and custom sports betting models.