The Detroit Tigers take on the St. Louis Cardinals tonight at Busch Stadium in a cross-league matchup. Let’s take a look at my Tigers vs Cardinals prediction for May 20, including the latest Tigers vs Cardinals odds, picks, and best bets from my AI model.

Preview of Tigers vs Cardinals Prediction

Tonight’s Tigers vs Cardinals game kicks off at 7:45 PM ET from Busch Stadium. Detroit is looking to bounce back after a rough stretch, while the Cardinals are hoping to stay hot at home. Both teams are navigating injury challenges, which could influence the Tigers vs Cardinals pick.

The model gives a slight edge to the Tigers, projecting a 5.0–4.0 win. But with the Cardinals as +1.5 underdogs at home, there's some betting value to explore.

Injury Report for Tigers vs Cardinals

Injuries are playing a major role in this Tigers vs Cardinals prediction. Here's a look at who’s out:

Cardinals:

• Zachary Thompson (D60 - Lat)

Tigers:

• Sawyer Gipson-Long (D60 - Hip)
• Casey Mize (D15 - Hamstring)
• Parker Meadows (D60 - Arm)
• Reese Olson (D15 - Finger)
• Matthew Vierling (D10 - Shoulder)
• Alexander Lange (D60 - Lat)
• Wenceel Pérez (D60 - Spine)
• Jacob Rogers (D10 - Oblique)
• Tyler Madden (D60 - Shoulder)

These absences, especially in Detroit's bullpen and outfield, add depth to the Tigers vs Cardinals injury outlook.

Who is Favored to Win Tigers vs Cardinals?

Despite the model favoring Detroit by a narrow 5–4 margin, sportsbooks have the Cardinals listed as +1.5 underdogs. This shows there's no overwhelming favorite, which makes this Tigers vs Cardinals pick more nuanced.

Tigers vs Cardinals History

When evaluating Tigers vs Cardinals trends, recent ATS performance tells the story:

• Tigers ATS (last 5): 1–4
• Cardinals ATS (last 5): 3–2
• Tigers as Favorite: 0–3 ATS
• Cardinals as Underdog: 2–1 ATS
• Tigers on the Road: 1–3 ATS
• Cardinals at Home: 1–0 ATS

These Tigers vs Cardinals trends support leaning toward St. Louis with the points.

How Many Times Has Cardinals Beat Tigers?

Historically, the Cardinals have a slight edge in interleague matchups against the Tigers, though it’s a small sample size. The Tigers vs Cardinals prediction today is more heavily influenced by recent team form and roster health than historical data.

Model Used for My Tigers vs Cardinals Best Bet Prediction

This pick comes from my Pre-Built MLB Rithmm Model, which incorporates:

• Recent team performance
• Run differential
• Starting pitcher impact
• Bullpen ERA
• Injury status and line movement

What Chance Does Cardinals Have of Beating Tigers?

According to my Rithmm model, the Cardinals have a 57.4% probability of covering the +1.5 run line, even if they don’t win outright. This makes them an appealing value for tonight’s Tigers vs Cardinals prediction.

Best Odds for Tigers vs Cardinals

Here’s the best Tigers vs Cardinals line for the Cardinals +1.5:

• Best Odds: FanDuel (-111)
• Other books are offering -115 to -120, so FanDuel stands out for this Tigers vs Cardinals best bet.

My Pick for Tigers vs Cardinals

Based on model insights and current injuries, my Tigers vs Cardinals pick is Cardinals +1.5 (-111). The Tigers are depleted and haven’t covered well as favorites. St. Louis, meanwhile, has covered 2 of their last 3 as underdogs.

This Tigers vs Cardinals best bet offers both value and alignment with my AI-driven prediction.

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This AI sports betting analysis is just a glimpse of what you can expect when using Rithmm. Whether you’re looking to refine your betting strategy or want to explore in-depth data trends, Rithmm's AI tools for sports betting has all you need. Don't miss out on making more informed decisions—download the Rithmm app today for full access to our AI baseball predictions, MLB Computer Picks, AI Player Props, and custom sports betting models.