Get ready for an interleague matchup tonight at Great American Ball Park as the Chicago White Sox take on the Cincinnati Reds. Let's take a look at my White Sox vs Reds prediction for today’s MLB action.

Preview of White Sox vs Reds Prediction

The Reds and White Sox meet in a cross-league clash on May 14 at 7:14 PM ET. This game will be played at Great American Ball Park, and both teams are searching for rhythm amid injury-heavy rosters. The White Sox are slight underdogs but have performed well ATS in recent games. In contrast, the Reds are struggling to meet expectations as home favorites.

This White Sox vs Reds prediction comes at a time when both teams are fighting through adversity. Cincinnati is trying to turn around their home woes, while Chicago looks to continue their underdog success.

Injury Report for White Sox vs Reds

Injuries play a major role in shaping today's White Sox vs Reds picks.

Reds Injury Report:

• Julian Aguiar & Brandon Williamson (D60 - Elbow)
• Terry Friedl (Day-to-Day - Wrist)
• Samuel Moll, Rhett Lowder & William Spiers (D15 - Shoulder/Forearm)
• Noelvi Marte, Jake Fraley (D10 - Side/Calf)
• Christian Greene (D15 - Groin)
• Francelis Montas (D60 - Lat)

White Sox Injury Report:

• Andrew Benintendi, Michael Tauchman, Austin Slater (D10 - Calf/Hamstring/Knee)
• Prelander Berroa, Kyler Bush (D60 - Elbow)
• Michael Kopech (D60 - Shoulder)
• Martín Pérez (D60 - Forearm)
• Korey Lee (D10 - Ankle)
• Fraser Ellard (D15 - Lat)

Both squads are depleted, with notable absences impacting both lineups and bullpens—critical for evaluating your White Sox vs Reds Best Bets.

Who is Favored to Win White Sox vs Reds?

The Reds are slight home favorites with the moneyline edge. However, model data suggests this could be a tightly contested matchup. Keep reading for insights into the best White Sox vs Reds pick tonight.

White Sox vs Reds History

Let’s examine recent White Sox vs Reds trends heading into tonight’s game:

• White Sox ATS Record (Last 5): 3-2-0
• Reds ATS Record (Last 5): 2-3-0
• White Sox as Underdogs: 3-2-0
• Reds as Favorites: 0-1-0
• White Sox Away: 1-1-0 | Reds Home: 0-1-0

These White Sox vs Reds trends indicate that the Sox have been stronger against the spread, especially as underdogs.

How Many Times Has White Sox Beat Reds?

The White Sox and Reds have limited recent head-to-head history. However, the data shows value on Chicago in these spots, especially when they're catching runs.

Model Used for My White Sox vs Reds Best Bet Prediction

I used Rithmm’s Pre-Built MLB model to evaluate this White Sox vs Reds prediction.

This model incorporates team injuries, recent trends, pitcher data, offensive metrics, and bullpen performance to determine the edge.

What Chance Does White Sox Have of Beating Reds?

Rithmm’s model predicts the Reds to win 5.0 to 4.0, but the White Sox +1.5 run line has a 55.4% win probability, making it today’s top-rated value bet.

Best Odds for White Sox vs Reds

Let’s shop the best odds for this White Sox vs Reds prediction:

• Best Odds: FanDuel & DraftKings: +1.5 (-108)
• Consensus Line: +1.5 (-109)

Multiple sportsbooks offer great value on the White Sox +1.5, aligning well with our AI model.

My Pick for White Sox vs Reds

Based on the model and current line value, the best White Sox vs Reds pick is:

White Sox +1.5 (-108)

Despite being banged up, the Sox have shown resilience, especially in underdog situations. Backing them to keep it close is today’s top AI-driven play.

Explore More White Sox vs Reds Predictions

Looking for more AI-powered predictions? Check out:

• AI Sports Betting insights for smarter decision-making.
• MLB AI Sports Predictions for advanced game insights.
• Computer MLB Picks for expert computer-driven predictions.
• MLB PrizePicks for AI PrizePick predictions.
• AI MLB Player Props for deeper in-game data

This AI sports betting analysis is just a glimpse of what you can expect when using Rithmm. Whether you’re looking to refine your betting strategy or want to explore in-depth data trends, Rithmm's AI tools for sports betting has all you need. Don't miss out on making more informed decisions—download the Rithmm app today for full access to our AI baseball predictions, MLB Computer Picks, AI Player Props, and custom sports betting models.